Antiinflammatory Effects of Budesonide in Human Fetal Lung
نویسندگان
چکیده
منابع مشابه
Anti-inflammatory effects of budesonide in human lung fibroblasts are independent of histone deacetylase 2
Correspondence: Stephen I Rennard University of Nebraska Medical Center, 985910 Nebraska Medical Center, Omaha, Nebraska 68198-5910, USA Tel +1 402 559 7313 Fax +1 402 559 4878 Email [email protected] Objective and design: Reduced expression of histone deacetylase 2 (HDAC2) in alveolar macrophages and epithelial cells may account for reduced response of chronic obstructive pulmonary disease (CO...
متن کاملAnti-inflammatory effects of budesonide in human lung fibroblast are independent of histone deacetylase 2
OBJECTIVE AND DESIGN Reduced expression of histone deacetylase 2 (HDAC2) in alveolar macrophages and epithelial cells may account for reduced response of chronic obstructive pulmonary disease (COPD) patients to glucocorticoids. HDAC2 expression and its role in mediating glucocorticoid effects on fibroblast functions, however, has not been fully studied. This study was designed to investigate wh...
متن کاملEffects of budesonide and formoterol on eosinophil activation induced by human lung fibroblasts.
Budesonide and formoterol are extensively used in current asthma therapy. Budesonide is known as potent antiinflammatory agent and formoterol also appears to have some antiinflammatory properties. We investigated inhibitory effects of these drugs on eosinophil activation in vitro as induced by fibroblast-conditioned medium (FCM). We measured the modulation of expression of clonal designator (CD...
متن کاملAntiinflammatory effects of reconstituted high-density lipoprotein during human endotoxemia
High-density lipoprotein (HDL) has been found to neutralize LPS activity in vitro and in animals in vivo. We sought to determine the effects of reconstituted HDL (rHDL) on LPS responsiveness in humans in a double-blind, randomized, placebo-controlled, cross-over study. rHDL, given as a 4-h infusion at 40 mg/kg starting 3.5 h before endotoxin challenge (4 ng/kg), reduced flu-like symptoms during...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Respiratory Cell and Molecular Biology
سال: 2016
ISSN: 1044-1549,1535-4989
DOI: 10.1165/rcmb.2016-0068oc